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Joint EMBL-EBI/Wellcome Trust Course: Resources for Computational
Drug Discovery

2-6 July 2012
Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

This event has now expired. Please click here to be redirected to the current course webpage.


This joint EBI-Wellcome Trust course aims to provide participants with the principles of chemical biology and how to use computational methods to probe, explore and modulate biological systems using chemical tools. The course will be comprised of a mixture of lectures and hands-on exercises. The conceptual framework will be covered along with direct practical experience of retrieving and analysing chemogenomics data. Participants will be able to do their own target analysis and identify appropriate chemical tools for probing biological systems of personal interest .

Target audience and learning objectives
The interdisciplinary and interactive programme is ideal for both academics and industrial researchers interested in drug discovery, or for researchers looking to progress from basic functional genomics to translational research. Participants should have a degree in a biomedical discipline. No previous training in bioinformatics is required but attendees should be comfortable with computers and Internet searching. The course will be highly interactive and will include problem solving sessions each day. Attendees are strongly encouraged to bring ideas for particular pieces of work to be addressed during these sessions. 

The overall aim of the course is to provide:

 - Knowledge of the content of publicly available bioactivity databases their use in identifying and selection of bioactive molecules for screening.
 - Knowledge and hand-on experience of computational chemistry and biology tools that can help in compound design and target evaluation.
 - Experience of using these tools for analysis of compounds and targets of personal interest.

Please note: Places on this course are limited and will be awarded on merit. Applicants must attach a completed application form when registering, please see below for full details.

Concepts of computational drug discovery
Publicly available databases and bioactivity resources
Compound design and virtual screening to expand bioactive chemical space
Selecting compounds to screen against novel targets and for target validation
Strategies for drug re-use and repositioning
Identification of off-target effects by cross-reactivity analysis
Target analysis and use of genomic data for drug discovery

Click here to download a DRAFT programme.

Scientific Programme Committee
John Overington, EMBL-EBI, UK
Anne Hersey, EMBL-EBI, UK
Vicky Schneider, EMBL-EBI, UK
James Watson, EMBL-EBI, UK

Trainers will include:
Bissan Al-Lazikani, Institute of Cancer Research, UK
Francis Atkinson, EMBL-EBI, UK
Michael Barnes, Queen Mary University of London, UK
Louisa Bellis, EMBL-EBI, UK
Andreas Bender, Cambridge University, UK
Anna Gaulton, EMBL-EBI, UK
Val Gillet, University of Sheffield, UK
Darren Green, GSK, UK
Anne Hersey, EMBL-EBI, UK
John Irwin, UCSF, USA
Noel O'Boyle, University College Cork, Ireland
John Overington, EMBL-EBI, UK
George Papadatos, EMBL-EBI, UK
Markus Sitzmann, National Cancer Institute, USA


Registration and Accommodation

The course is subsidised by the Wellcome Trust and there is a registration fee of 500, which includes registration, meals and accommodation for the nights of the 2, 3, 4 and 5 July 2012.


Please note: Places on this course are limited and will be awarded on merit. Applicants must attach a completed application form in the 'Abstract Submission' section of online registration. The supervisor's section MUST be completed when the application form is attached. Registrations cannot be accepted without a completed application form.

The application deadline for this course has now passed. Please email to join our mailing list for future course dates.

Course contact
if you require any further information, please contact the course administrator at:


 Gibbs Building, 215 Euston Road, London NW1 2BE, UK   tel:+44 (0)20 7611 8888