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1-3 March 2010


Wellcome Trust Conference Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK


With the US National Institute of Health’s Molecular Library Initiative and the EMBL-European Bioinformatics Institute’s chemogenomics and cheminformatics programmes, large-scale drug discovery and biological screening data have entered the public domain. We are also witnessing the first efforts to sequence individual human genomes, and are making impressive progress in understanding the genomes of some of the world’s most significant disease-causing organisms. Integration of genomic sequence information with proteomics and metabolomics data provides an unprecedented chance to systematically attack disease on a molecular level. Open access to bioinformatics and cheminformatics data also opens up exciting new opportunities for academic–industrial collaboration. TACBAC 2010 will bring together experts from both the biomedical and the computational domains to explore these novel developments, discuss how to overcome the major challenges, and create new opportunities for applying computational biology and chemistry to disease management and prevention.



Scientific Programme Committee:


Conference co-chairs

  • John Overington: EMBL-European Bioinformatics Institute, HInxton
  • Christoph Steinbeck: EMBL-European Bioinformatics Institute, HInxton



Final Programme


Spoken Presentations: If you are an invited speaker or your abstract has been selected for an oral presentation, please give an electronic version of your talk to the AV technician in the Francis Crick Auditorium the morning of your presentation.


Poster Presentations: If your abstract has been selected for a poster please display this in the Cloisters. Your page number corresponds to your poster board number.



Monday 1st March 2010

10:00   Registration open and exhibitor setup

Conference Centre Foyer and Cloisters

12:30   Lunch

Hinxton Hall Restaurant


Francis Crick Auditorium


14:00   Welcome address

Janet Thornton, EMBL-EBI

14:15   Opening keynote:

Genomes, structural biology and drug discovery: where computational biology can contribute

Tom Blundell, University of Cambridge



Session 1a: Drug Discovery in Not-For-Profit Organisations

Chair: Alexander Tropsha


15:00   An integrated informatics approach toward small molecule biological probe and drug discovery

Alexander Tropsha, University of North Carolina at Chapel Hill

15:30   Drugging the cancer genome: Examples of HSP90 and PI 3-kinase inhibitors

Paul Workman, Institute of Cancer Research

16:15   Afternoon Tea

Conference Centre Cloisters

16:45   New therapies for treating cancer and inflammation

Dennis Liotta, Emory University

17:15   Open access chemical probes for epigenetic readers and writers: systems biology meets systems chemistry

Tom Heightman, University of Oxford

17:45   Robot chemists for system biologists: designing polypharmacolgy through

automated lead optimisation

Andrew Hopkins, University of Dundee

18:15   Welcome reception

Conference Centre Cloisters

19:00   Dinner

Hinxton Hall Restaurant



Tuesday 2nd March 2010

7:30     Breakfast

Hinxton Hall Restaurant


Francis Crick Auditorium


Session 1b: Drug Discovery in Not-For-Profit Organisations - continued

Chair: Paul Wyatt


09:00   Repositioning enzyme targets for neglected diseases drug discovery

Paul Wyatt, University of Dundee

09:30   Development of 11ß-HSD1 inhibitors within a medical school

Brian Walker, University of Edinburgh

10:00   Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction

Ian Hardcastle, Newcastle University

10:30   Morning Coffee

Conference Centre Cloisters

11:00   A short introduction to pre-competitive pharmaceutical informatics activities and forums

Ian Dix, AstraZeneca, Alderley Park

11:15   New medicines to improve control and contribute to the eradication of malaria

Tim Wells, MMV Geneva

11:45   Precompetitive standards for accelerated drug discovery

Lee Harland, Pfizer Regenerative Medicine, Cambridge and the Pistoia Alliance

12:15   Lunch and Exhibition

Conference Centre Cloisters


Session 2: Large-Scale Predictive Approaches

Chair: Tudor Oprea


14:00   Large-scale analyses of chemogenomic data

Tudor Oprea, University of New Mexico

14:30   Systemic approaches to study drug-target clinical effects

Olivier Taboureau, Danish Technical University

15:00   Benchmarking ligand-based approaches to in silico target profiling

Jordi Mestres, Municipal Institute of Medical Research

15:30   Afternoon Tea

Conference Centre Cloisters

16:00   Integrating multiple sources of toxicology data using the public ToxML data exchange format

Glenn Myatt, Leadscope Inc. (short talk selected from Abstract)

16:15   Understanding polypharmacology in silico, in vitro and by probing GPCR structures

Jonathan Mason, Heptares Therapeutics Ltd, Welwyn Garden City

16:45   Influencing drug design using safety data

Scott Boyer, AstraZeneca a MöIndal

17:15   Poster session,

EMBL-EBI and BioBase database demonstrations,

Pre-dinner drinks

Conference Centre Cloisters

18:30   Pre-dinner keynote:

Progress (and reasons for the lack thereof) in computer-aided drug design

Garland Marshall, Washington University

19:15   Conference Dinner

Hinxton Hall Restaurant


Wednesday 3rd March 2010

7:30     Breakfast

Hinxton Hall Restaurant


Francis Crick Auditorium


Session 3: Physiological and Metabolic Systems Biology

Chair: Elaine Holmes


09:00   Through the metabolic looking glass

Elaine Holmes, Imperial College, London

09:30   Knowledge representation in systems biology

Nicolas Le Novère, EMBL-European Bioinformatics Institute, Hinxton

10:00   An update on the Human Metabolome Project

David Wishart, University of Alberta, Edmonton

10:30   Morning Coffee

Conference Centre Cloisters

11:00   Predicting selective drug targets in cancer through metabolic network modelling

Ori Folger, Tel Aviv University (short talk selected from abstract)

11:15   Modelling the complexity of nutrition and health interactions by nutritional metabonomics

Francois-Pierre Martin, Nestlé

11:45   LC-MS in metabolomics: challenges and opportunities

Thomas Hankemeier, Netherlands Metabolomics Centre

12:15   Lunch and Exhibition

Conference Centre Cloisters



Session 4: Public Infrastructure for Screening

Chair: Stephen Bryant


14:00   PubChem: an open repository for chemical structure and biological activity information

Stephen Bryant, US National Center for Biotechnology Information

14:30   Community-driven development of novel and diverse high-throughput screening

projects in the NIH roadmap Molecular Libraries Program

Mark Scheideler, US National Institute of Neurological Disorders & Stroke

14:45   EU-OPENSCREEN, a European research infrastructure of open screening platforms

for chemical biology

Ronald Frank, Leibniz-Institut für Molekulare Pharmakologie

15:00   Keynote: Synthetic approaches to the disruption of protein-protein interactions

involved in oncogenesis

Andrew Hamilton, University of Oxford

15:45   Afternoon Tea

Conference Centre Cloisters

16:15   DSSTOX and chemoinformatics technologies in support of ToxCast and Tox21 HTS toxicity screening programs

Ann Richard, National Center for Computational Toxicology

16:45   ChemSpider – a community platform for chemistry and resources supporting

the life sciences

Antony Williams, Royal Society of Chemistry

17:15   CSAR, Community Structure-Activity Resource

Heather Carlson, University of Michigan

17:45   Closing remarks

John Overington and Chris Steinbeck, EMBL-EBI, Hinxton

18:00   Close of Conference




Registration Fees:


Due to the generous financial support of the Wellcome Trust and EMBL-European Bioinformatics Institute we are able to offer subsidised registrations as follows:



No Accommodation



Twin Accommodation

sold out


Single  Accommodation

Sold out


No Accommodation



Twin Accommodation

sold out


Single Accommodation

sold out


No Accommodation 



Twin Accommodation

Sold out


Single Accommodation 

Sold out

EBI Industry Programme Member

No Accommodation


EBI Industry Programme Member

Twin Accommodation

Sold Out

EBI Industry Programme Member

Single Accommodation

Sold Out


* If you require accommodation, please contact the Wellcome Trust Conference Centre directly,, +44 (0)1223 495000



NEW - Abstract Deadline – Monday 18th January 2010

Abstracts can be uploaded during the registration process, see link below

Abstracts will be invited as Poster or Oral presentations. You will receive confirmation of which, within approximately 2 weeks after the abstract deadline.

Registration Deadline – Monday 18th January 2010


After the abstract deadline the scientific committee will be selecting 5 abstracts for  oral presentations. Those that are selected will receive reimbursement of their registration fee, and an allowance towards their travel costs*.


* Allowance to be confirmed once selected




The housing packages include registration, food and accommodation for the night of Monday 1st and Tuesday 2nd March 2010, at the Wellcome Trust Conference Centre. 


The no housing package includes all costs accept accommodation. 



Important – limited on-site accommodation

As we have limited bedrooms on-site, bedrooms will be allocated on a first come, first serve basis. Early registration is recommended. Once we have reached capacity and accommodation is no longer a registration option, delegates are advised to make their own accommodation arrangements.


A complimentary shuttle service will run between Cambridge City Centre and the Conference Centre, once in the morning and once in the evening, once accommodation is fully booked.





 Gibbs Building, 215 Euston Road, London NW1 2BE, UK   tel:+44 (0)20 7611 8888